![]() ![]() Their results demonstrate the utility of this technique, which will help us in our fight against our ancient foe.Įstimates suggest that around two-thirds of the global population is infected with herpes simplex virus type 1 (HSV-1), the virus that causes cold sores and genital herpes. Using soft X-rays to produce 3D images of the virus as it infects cells, they've discovered interesting changes to cell morphology. In work recently published in PLOS Pathogens, researchers from the University of Cambridge have collaborated with Diamond's B24 beamline to exploit a new 3D imaging technique using Cryo Soft X-ray Tomography (Cryo-SXT). Traditional imaging techniques such as transmission electron microscopy and fluorescence microscopy often need samples that have been processed – by fixing, staining, and sectioning – and that can introduce artefacts. ![]() However, getting a good view of cells in their natural state is challenging. To separate ourselves from this pathogen, we need a better understanding of how it hijacks our cells to make copies of itself. ![]() Humanity has always been plagued by herpes simplex virus type 1 (HSV-1), which causes cold sores and genital herpes and is implicated in long-term neuropathologies.
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